SEDONA SENIOR LONGEVITY
Welcome to the timely launch of the 'SSLONGEVITY' weblog vessel on her maiden voyage! Plenty of room for everyone. This is an open public forum for exchanging information on healthy life extension techniques for seniors and those who will become seniors. Let us all join in the quest for longer, richer lives for those with the life experience, wisdom and perspective much needed in today's world. Let Senior Power! become an enduring trend.
Comments encouraged from all.
Steveaux
July 18, 2024: Thanks to Geno and Patti for a great presentation today. I hope all attendees will join in the discussion here, and spread the word to others. Just a disclaimer: this site is for information exchange and social interaction only, and is not intended for medical diagnosis, prescription, or treatment. Pursuant to today's session, here is a good reference to the book that was featured, 'How Not to Age' by Michael Gregor:
ReplyDeletehttps://nutritionfacts.org/book/how-not-to-age/
Another book I would recommend is 'Bursting with Energy' by Dr. Frank Shallenberger:
https://books.google.com/books/about/Bursting_with_Energy.html?id=OXlWngEACAAJ
Dr. Shallenberger explains how low energy production is behind most of our disease and aging problems. He tells how to optimize our metabolism, and provides a total diet, exercise and lifestyle regimen to slow the aging process to "a snail's pace". Very informative!
I'm glad to see continued interest in stress as a cause of aging. In particular, I think Oxidative Stress needs more attention, especially as scientific studies have determined that antioxidants can not only relieve stress, but can significantly extend lifespan --a discovery that confutes the usual claim that only calorie restriction has been proven to increase lifespan. Here are a few brief excerpts from "Life Extenders and Memory Boosters", -Hans Kugler, Ed.
ReplyDelete[T]hese researchers...assert that simply put: nutritional supplements seem to have important, life-extending anti-cancer effects. (p. 17)
"The free radical theory of aging predicts that the healthy life span can be increased by minimizing deleterious free radical reactions while not significantly interfering with those essential to the economy of the cells and tissues." (p. 42)
Superoxide Dismutase
The lifespans of some one dozen mammalian species have been positively correlated with the amounts of SOD found in their bodies.... (p. 43)
Nordihydroguairetic acid [antioxidant]
In other words, the NGDA that was fed to the mice not only extended their lives but prevented their physical appearance from prematurely aging. (p. 56)
2-Mercaptoethylamine (MEA)
Dr. Denham Harman (1981) notes that the addition of MEA to the diets of experimental mice "increased the life span by 30 percent; this increase is equivalent to raising the human life span from 73 to 95 years." (p. 57)
Calorie Restriction Myth Exploded [chromium picolinate]
For years, mainstream scientists have maintained that the only way to obtain significant advances in life extension is to cut calories...
The rats receiving chromium picolinate lived an average of one year longer than the others...Their life spans had been increased by 33%. (p. 70-71)
Thanks to Geno for bringing up the generation of Nitric Oxide and its physiological effects. The processes involving NO are indeed complicated: although small amounts of NO in the cells and bloodstream may induce relaxing effects in muscle tissue, larger amounts can have deleterious effects such as glycosylation and mitochondrial malfunction. The language of scientific literature can at times become impenetrable for the non-specialist, but from these abstracts a general sense of caution can be gleaned:
ReplyDeletehttps://pubmed.ncbi.nlm.nih.gov/28937232/
Physiology of nitric oxide in the respiratory system
M Antosova 1, D Mokra, L Pepucha, J Plevkova, T Buday, M Sterusky, A Bencova
Abstract
Nitric oxide (NO) is an important endogenous neurotransmitter and mediator. It participates in regulation of physiological processes in different organ systems including airways. Therefore, it is important to clarify its role in the regulation of both airway and vascular smooth muscle, ...
https://www.sciencedirect.com/science/article/abs/pii/S108986031830315X
The effect of nitric oxide on mitochondrial respiration
Juan José Poderoso a b, Katia Helfenberger c d, Cecilia Poderoso c d
Abstract
This article reviews the interactions between nitric oxide (NO) and mitochondrial respiration. Mitochondrial ATP synthesis is responsible for virtually all energy production in mammals, and every other process in living organisms ultimately depends on that energy production. Furthermore, both necrosis and apoptosis, that summarize the main forms of cell death, are intimately linked to mitochondrial integrity.
Endogenous and exogenous •NO inhibits mitochondrial respiration by different well-studied ...
What I find most interesting is that the breathing exercise Geno introduced is very similar to a somewhat more complicated Yoga process called Uddiyana Bandha:
https://yogainternational.com/article/view/uddiyana-bandha-step-by-step/
I suspect these types of breathing suspension exercises have the salutary effect of creating an oxygen demand in the cells throughout the body, making them 'oxygen hungry'. This in turn could lead to more efficient and effective aerobic metabolism when oxygen is resupplied, rather similar to working up a hearty appetite before eating: the hunger demand will produce more thorough utilization of nutrients...possibly. I cannot comment on the role nitric oxide might play in this.